Since the middle of the 20th century, suicidology, as a group of disciplines working to understand and prevent suicide, has reinforced the long-held view that suicide is caused first and foremost b...

Summary Watters questions the universality of mental illness and warns of the harms that accompany the exportation of Western typologies to non-Western cultures. He is particularly concerned that these effects will be exacerbated by the upcoming revisions of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Building on his examination of non-Western practices, Watters exposes the historical instability of mental health classifications in North America to question the validity of current DSM categories. Although Watters' warnings about the dangers of (...) the globalisation of the DSM are persuasive, they may be overreaching as our examination of the successful incorporation of Western created autism services, information, and interventions in the developing world suggests. (shrink)

In El Salvador from 1978 to 1988, contraceptive use among married women 15–44 years of age increased from 34% to 47%, and the total fertility rate declined from 6·3 to 4·6 children per woman. Most of this change took place from 1978 to 1985. Sterilization is the most prevalent method used, but nearly one-half of the women who are sterilized did not use any contraception before their operation. Few young couples use reversible methods of contraception to space births or delay (...) the start of childbearing. On average, women wait 8 years after marriage and have nearly three children before they use contraception. (shrink)

Summary Using the neurological syndrome kuru as a frame, Warwick Anderson examines the social dynamics and material culture of its medical investigation among the Fore people conducted by D. Carleton Gajdusek beginning at midcentury. The Collectors of Lost Souls: Turning Kuru Scientists into White Men uses a postcolonial framework to complicate dominant/subordinate binaries and diffusionist accounts of indigenous contacts with medical science. Anderson proposes that colonies are specific sites of production of medical knowledge. He draws a distinction between traditional and (...) advanced economies in regard to individual rights to make an argument in support of context-specific ethical regulation for medical research and suggests a role for historians of science in interrogating the process of globalisation. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Employing the National Institute of Mental Health-funded Prevention of Suicide in Primary Care Elderly Collaborative Trial as a case study, we discuss 2 sets of ethical issues: obtaining informed consent for a clinic-based intervention study and using treatment as usual (TAU) as the control condition. We then address these ethical issues in the context of the debate about the quality improvement efforts of health care organizations. Our analysis reveals the tension between ethics and scientific integrity involved with using TAU as (...) a control condition and the difficulty in designing high-quality research in a community-based setting. (shrink)

Although sensorimotor contingencies may explain visual perception, it is difficult to extend this concept to speech perception. However, the basic concept of perception as active hypothesis testing using attention does extend well to speech perception. We propose that the concept of sensorimotor contingencies can be broadened to sensory-attentional contingencies, thereby accounting for speech perception as well as vision.

We often find ourselves in situations where it is up to us to make decisions on behalf of others. How can we determine whether such decisions are morally justified, especially if those decisions may change who it is these others end up becoming? In this paper, I will evaluate one plausible kind of justification that may tempt us: we may want to justify our decision by appealing to the likelihood that the other person will be glad we made that specific (...) choice down the line. Although it is tempting, I ultimately argue that we should reject this sort of appeal as a plausible justification for the moral permissibility of our vicarious decisions. This is because the decisions that we make on behalf of another may affect the interests and values that that person will hold in the future. As I will show, this complicates the justificatory relationship between present decisions and future attitudes, since the latter can depend on the former. This is not to say that the predicted future attitudes of others can play no significant role in justifying our decisions on others’ behalf. Rather, appealing to the future attitudes in our moral justifications may play an important role in our practical thinking but only when we consider the future attitudes of all relevant possible futures. (shrink)

We develop a logical modelling approach to describe evolvable computational systems. In this account, evolvable systems are built hierarchically from components where each component may have an associated supervisory process. The supervisor's purpose is to monitor and possibly change its associated component. Evolutionary change may be determined purely internally from observations made by the supervisor or may be in response to external change. Supervisory processes may be present at any level in the component hierarchy allowing us to use evolutionary behaviour (...) as an integral part of system design. We model such systems in a revision-based first-order logical framework in which supervisors are modelled as theories which are at a logical meta-level to the theories of their components. This enables evolutionary change of the component to be induced by revision-based changes of the supervisor at the meta-level. In this way, the intervention required in evolutionary change is modelled purely logically. The hierarchical component-based structure is fairly intricate so we present the basic ideas firstly in a simple setting, the well-known blocks world, before introducing tree-based structures to represent component hierarchies. We also introduce some techniques for establishing the behaviour of evolvable systems specified in this logical framework. The ideas and concepts are driven by example throughout. We conclude with a more substantial example, that of a simple model of an evolvable system of automated bank teller machines. (shrink)

The influence of Kant's philosophy has been, and continues to be, so profound and so widespread as to have become imperceptible. Philosophical inquiry within both the ‘analytic’ and the ‘continental’ traditions is unthinkable without the lexical and conceptual resources bequeathed by Kant. Even outside philosophy, in the humanities, social sciences and natural sciences, Kantian concepts and structures of argument are ubiquitous. Anyone practicing literary or social criticism is contributing to the Kantian tradition; anyone reflecting on the epistemological implications of their (...) work will find themselves doing so within parameters established by Kant. Indeed, many contemporary debates, whether in aesthetics, literary or political theory, show a peculiar tendency to mutate into disputes in Kant exegesis. All in all, in the less than 200 years since the death of its author, Kantian philosophy has established itself as an indispensable point of intellectual orientation. (shrink)

The New Zealand philosopher, Robert Nola (1940-2022), has died. He was a kind man, a good friend, and a fine philosopher. Here is how I remember him.

Background: Current practice frequently fails to provide care consistent with the preferences of decisionally-incapacitated patients. It also imposes significant emotional burden on their surrogates. Algorithmic-based patient preference predictors (PPPs) have been proposed as a possible way to address these two concerns. While previous research found that patients strongly support the use of PPPs, the views of surrogates are unknown. The present study thus assessed the views of experienced surrogates regarding the possible use of PPPs as a means to help make (...) treatment decisions for decisionally-incapacitated patients. -/- Methods: This qualitative study used semi-structured interviews to determine the views of experienced surrogates [n=26] who were identified from two academic medical centers and two community hospitals. The primary outcomes were respondents’ overall level of support for the idea of using PPPs and the themes related to their views on how a PPP should be used, if at all, in practice. -/- Results: Overall, 21 participants supported the idea of using PPPs. The remaining five indicated that they would not use a PPP because they made decisions based on the patient’s best interests, not based on substituted judgment. Major themes which emerged were that surrogates, not the patient’s preferences, should determine how treatment decisions are made, and concern that PPPs might be used to deny expensive care or be biased against minority groups. -/- Conclusions: Surrogates, like patients, strongly support the idea of using PPPs to help make treatment decisions for decisionally-incapacitated patients. These findings provide support for developing a PPP and assessing it in practice. At the same time, patients and surrogates disagree over whose preferences should determine how treatment decisions are made, including whether to use a PPP. These findings reveal a fundamental disagreement regarding the guiding principles for surrogate decision-making. Future research is needed to assess this disagreement and consider ways to address it. (shrink)

I propose and defend a novel view called “de se consequentialism,” which is noteworthy for two reasons. First, it demonstrates—contra Doug Portmore, Mark Schroeder, Campbell Brown, and Michael Smith, among others—that agent-neutral consequentialism is consistent with agent-centered constraints. Second, it clarifies the nature of agent-centered constraints, thereby meriting attention from even dedicated nonconsequentialists. Scrutiny reveals that moral theories in general, whether consequentialist or not, incorporate constraints by assessing states in a first-personal guise. Consequently, de se consequentialism enacts constraints through the (...) very same feature that nonconsequentialist theories do. (shrink)

In I 7 Aristotle lays down criteria for what is to count as human happiness. Happiness for man is self-sufficient , complete without qualification , peculiar to humans , excellent , and best and most complete . Many interpreters agree that in X 6–8 Aristotle uses these along with other criteria to disqualify the life of amusement and rank one happy life above another.

Having for thirty years believed and taught the doctrine of phlogiston… I for a long time felt inimical to the new system, which represented as absurd that which I hitherto regarded as sound doctrine; but this enmity… springs only from force of habit… [Black to Lavoisier, 1791]This paper is abstracted from a forthcoming book which defends a particular answer to the question of just what it is that shifts when a paradigm shifts. The claim is that what shifts are habits (...) of mind. And in particular the claim is that the most striking cases of paradigm shift will characteristically turn on a shift in some single, uniquely critical, habit of mind: the barrier. An account of a radical discovery — discovery that prompts the Kuhnian symptoms of incommensurability, so that intuitions that seem irresistible to some seem perverse to their rivals — then characteristically turns on how some individual got past the barrier (escaped the critical habit of mind), while at least for a while others could not do so. (shrink)

Science is one faith and has one great commandment. The faith is simply that man can control his future in his own interest. In the face of the appalling discrepancy between the powers of the natural and the social sciences, a discrepancy that leads to visions of man's liquidation by man, the assertion is nevertheless made that the remedy for the consequences of science is more science. The long record of scientific victories in the past gives some warrant, let us (...) suppose, for faith in continued victory, but at bottom there is no compelling proof. There never has been, and, I make bold to say, there never will be. The role of scientist in the human drama always contains lines reminiscent of Prometheus; an utterly nonrational belief in ultimate triumph lends him strength to confront what to others may seem a hopeless future. The frequency with which it will appear in the references is not because the writer regards it as of major importance, but because it dovetails more neatly with this paper than do many other more significant books. Moreover, it has fairly full footnote and chapter bibliographies. The statements in the non-parenthetical part of this paragraph are good examples of the near-elliptical character of much of what is said here. Expansion is badly needed, but the reader must be referred to ch. vi of. The position represented is not new; many writers, among them William James, have held it in various ways.). (shrink)

We might be tempted to think that, necessarily, if God unsurpassably loves such created persons as there may be, then for any capable created person S and time t, God is at t open to being in a positively meaningful and reciprocal conscious relationship with S at t, where one is open to relationship with another only if one never does anything (by commission or omission) that would have the result that the other was prevented from being able, just by (...) trying, to participate in that relationship. I argue that we should resist the temptation. (shrink)

In this paper I provide an interpretative reading Spencer and Gillen. What is read depends in part on what one is looking for, on the purposes for which it is being read, and, what is there to be read depends partly on the audiences that the author has in. I provide a critique of social Darwinist and post-colonial readings of their work. I employ the concept of a motivating theme, which can be applied to segments of the text, which share (...) a common purpose. The themes reflect the ways in which different scholars — historians and anthropologists — have read into the text. I will consider three categories of motivating themes: general contextualisations, ethnographic descriptions, and explanations of data. My discussion of their explanatory approach is centred on their analysis of ritual performances. The accounts of the rituals are not just unanalysed ethnography but are ordered by relating ritual event to social organisation. The centrality of ritual to Aboriginal society has contributed to the lasting impact of their work. (shrink)

There is considerable evidence that the hippocampal system contributes both to (1) the temporary maintenance of memories and to (2) the processing of a particular type of memory representation. The findings on amnesia suggest that these two distinguishing features of hippocampal memory processing are orthogonal. Together with anatomical and physiological data, the neuropsychological findings support a model of cortico-hippocampal interactions in which the temporal and representational properties of hippocampal memory processing are mediated separately. We propose that neocortical association areas maintain (...) shortterm memories for specific items and events prior to hippocampal processing as well as providing the final repositories of long-term memory. The parahippocampal region supports intermediate-term storage of individual items, and the hippocampal formation itself mediates an organization of memories according to relevant relationships among items. Hippocampal-cortical interactions produce (i) strong and persistent memories for events, including their constituent elements and the relationships among them, and (ii) a capacity to express memories flexibly across a wide range of circumstances. (shrink)

It is a standard feature of modern philosophy, at least from Locke, to tie together the questions of how we perceive the world and what we have reason to think the world is like in itself. This is a natural connection, because the questions of how we perceive it, and what kind of conception of it we can best form on the basis of that mode of perception, are obviously intimately linked. Part I of this volume defends the sense-datum theory (...) of perception against its opponents, and argues that the sense-datum theory is much closer to a form of direct realism than is normally thought: we directly perceive the world in the form that it naturally manifests itself to creatures like us. This leaves open the question of what it is like in itself, and Part II tries to show that a Berkeleian interpretation—that the world is a nomological structure in the mind of God—is the most plausible option. Arguments with roots in Berkeley, in modern philosophers such as John Foster, and in modern science, are drawn on to support this conclusion. (shrink)

This paper addresses a recent puzzle in the ethics of emotions concerning the fitting duration of emotions. On the one hand, many of our emotions tend to fade with time and can seem to do so fittingly. Think of attitudes like anger, grief, and regret. On the other hand, it's difficult to see how it could be fitting for these feelings to fade since the facts that make them fitting can seem to persist. This is the puzzle in brief; that (...) of explaining how certain feelings can fittingly fade with time. This paper argues that this puzzle has no general solution: in a wide range of true‐to‐life cases our fitting feelings remain fitting forever, until the day that we die. I conclude by exploring the normative significance of this result and its implications for the ethics of attitudes more generally. (shrink)

The normative notion of fittingness figures saliently in the work of a number of ethical theorists writing in the late nineteenth and mid-twentieth centuries and has in recent years regained prominence, occupying an important place in the theoretical tool kits of a range of contemporary writers. Yet the notion remains strikingly undertheorized. This article offers a (partial) remedy. I proceed by canvassing a number of attempts to analyze the fittingness relation in other terms, arguing that none is fully adequate. In (...) explaining why various analyses of fittingness fail, I draw into relief certain of the relation’s constitutive features and spotlight some of its interesting and important connections to various other properties. Along the way, I highlight the relation’s relevance to a number of ongoing debates in normative and metanormative philosophy. I conclude by indicating some directions for further research. (shrink)

Does faith that p entail belief that p? If faith that p is identical with belief that p, it does. But it isn’t. Even so, faith that p might be necessarily partly constituted by belief that p, or at least entail it. Of course, even if faith that p entails belief that p, it does not follow that faith that p is necessarily partly constituted by belief that p. Still, showing that faith that p entails belief that p would be (...) a significant step in that direction. Can we take that step? In this essay, I assess, and reject, seven reasons to think we can. Along the way, I discuss having faith in a person, being a person of faith, believing something by faith, and believing a person. (shrink)

The contemplation of the end of life — life's ending — provokes the emotions of fear, alarm and despondency. Fears about the end of life are almost universal. The Stoic Zeno of Elea first analyzed the problem accurately when he pointed out what he thought the fundamental problems of human existence consisted of. He identified the fundamental anxieties as being fear of the gods and a fear of death. Both fears, he thought, could be therapeutically eliminated: fear of the gods (...) was pointless since they did not care about us, and fear of death could be rationalized away by reasonable philosophical argumentation. Without wishing to resurrect Zeno's arguments, one can safely say that he was spectacularly wrong in his view of the power of rational argument. The fears about life's ending are multifaceted. They consist of fears about the process of aging, the prospect of one's own dying and one's own death, and the fact that our lives and activities — as they are lived within the confines of our corporeal bodies — will come to an inevitable end.There are also problems and anxieties concerned with the fact that the passage of time and the visible effects it leaves on our physical selves make us conscious that, at some time or other, we are, like other material objects, subject to decay and wearing down. The process is a great equalizer and no one who lives long enough is spared the spectacle of witnessing and experiencing the gradual process of the decline of their physical powers and of their cognitive functions. No matter what sort of life has been led, the ending of that particular life is certain.In this paper I want to discuss some views about the nature of these fears about the later stages of life, aging, old age and death and their roots in the philosophical and metaphysical views we have come to endorse. (shrink)

While it is tempting to suppose that an act has moral worth just when and because it is motivated by sufficient moral reasons, philosophers have, largely, come to doubt this analysis. Doubt is rooted in two claims. The first is that some facts can motivate a given act in multiple ways, not all of which are consistent with moral worth. The second is the orthodox view that normative reasons are facts. I defend the tempting analysis by proposing and defending a (...) heterodox account of both normative and motivating reasons that is inspired by Donald Davidson’s primary reasons. We should adopt the heterodox view, I argue, because it addresses an overlooked but fatal defect in the orthodox conception of reasons, of which challenges to the tempting analysis are a special case. (shrink)